ETS2 and COP1

Number of citations of the paper that reports this interaction (PubMedID 26496610)
430

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology)

		ETS2	COP1
Description		ETS proto-oncogene 2, transcription factor	COP1 E3 ubiquitin ligase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane	Golgi Membrane Nucleoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Oncogene Induced Senescence	Autodegradation of the E3 ubiquitin ligase COP1 Neddylation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) Central corneal thickness ( 32528159) Eye morphology ( 29921221) Fibrinogen levels ( 28107422) Finger osteoarthritis severity (hand Klsum) ( 33055079) Fractures ( 30158200) Intraocular pressure ( 29617998) Non-small cell lung cancer (survival) ( 21079520) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) TPE interval (response to exercise) ( 32386560)
Interacting Genes		22 interacting genes: CDK10 COP1 CREBBP EP300 ERG ETS1 FOS GATA3 HMGN1 JUN MFSD14B NCOR1 NR3C1 POU5F1 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11	20 interacting genes: CCT4 CDKN1B CUL4B DET1 ETS1 ETS2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 SOX2 STK40 TP53 TRIB1 UBE2D1 UBE2D2 YWHAZ
Entrez ID		2114	64326
HPRD ID		01263	07455
Ensembl ID		ENSG00000157557	ENSG00000143207
Uniprot IDs		P15036	Q8NHY2 X5D7N8 X5DNY7
PDB IDs		4BQA 4MHV	5HQG 5IGQ
Enriched GO Terms of Interacting Partners?
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