ETFA and CSK

Number of citations of the paper that reports this interaction (PubMedID 29987050)
17

Data Source:
BioGRID (genetic interference)

		ETFA	CSK
Description		electron transfer flavoprotein subunit alpha	C-terminal Src kinase
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Electron Transfer Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Protein Kinase A Catalytic Subunit Binding Identical Protein Binding Metal Ion Binding Proline-rich Region Binding
	Biological Process	Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase	Adaptive Immune Response Protein Phosphorylation Brain Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Peptidyl-tyrosine Phosphorylation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Negative Regulation Of Bone Resorption Protein Autophosphorylation Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus
Pathways		Respiratory electron transport	GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains Integrin signaling PD-1 signaling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOH GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Negative regulation of FLT3
Drugs			Dasatinib Staurosporine TG-100801 Fostamatinib
Diseases
GWAS		Diverticular disease ( 30177863) Glioma ( 28346443) Heel bone mineral density ( 30598549) Non-glioblastoma glioma ( 28346443 26424050) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Blood pressure ( 21909110) Blood protein levels ( 30072576) Body mass index and systole blood pressure (pairwise) ( 33619380) Caffeine consumption ( 21490707) Coffee consumption ( 31959922) Diastolic blood pressure ( 26390057 19430479 19430483) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Hypertension ( 31513605) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Serum albumin level ( 29403010) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Systolic blood pressure ( 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
Interacting Genes		15 interacting genes: BNC1 CDC42 CHRNA3 COX7C CSK CYP11A1 ETFB FAH FBXL17 HSPB2 LINC00597 MOV10L1 PSEN1 TNFRSF11A VCAM1	53 interacting genes: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDC45 CDH5 CREBBP DAB2 DOK1 DOK2 DOK3 ETFA FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KANK4 KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PDPK1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RB1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 UBE2I ZAP70 ZNF212
Entrez ID		2108	1445
HPRD ID		01979	00496
Ensembl ID		ENSG00000140374	ENSG00000103653
Uniprot IDs		A0A0S2Z3L0 P13804	A8K3B6 B2R6Q4 P41240
PDB IDs		1EFV 1T9G 2A1T 2A1U	1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?