ERH and PSMA6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ERH	PSMA6
Description		ERH mRNA splicing and mitosis factor	proteasome 20S subunit alpha 6
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GO Annotations	Cellular Component	Nucleus Midbody Methylosome	Proteasome Complex P-body Nucleus Nucleoplasm Cytosol Proteasome Core Complex Polysome Nuclear Matrix Proteasome Core Complex, Alpha-subunit Complex Myofibril Sarcomere Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Methyl-CpG Binding	RNA Binding Endopeptidase Activity Protein Binding Purine Ribonucleoside Triphosphate Binding NF-kappaB Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleoside Metabolic Process Cell Cycle	Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Proteolysis Involved In Cellular Protein Catabolic Process
Pathways			Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs			(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Creatine kinase levels ( 29403010) Psoriasis ( 25903422 20953189)
Interacting Genes		25 interacting genes: APP ATP6V0C CENPH CHTOP CIZ1 COPS6 CSNK2A1 CSNK2A2 CTDP1 CYSRT1 HSPA8 IFITM10 IGSF21 MED31 POLDIP3 PSMA6 RBM48 RPS6KA5 SETDB1 SH3GL2 TASOR2 TLE1 TP53 UNC119 UPRT	36 interacting genes: ALKBH4 BRCA1 BRME1 C19orf47 CADM1 ECT2 ERH HSPB1 KRTAP4-2 LIG4 LIMD2 NEDD8 PAXIP1 PLK1 POLR2L PSMA2 PSMA3 PSMA4 PSMA7 PSMB5 PSMB6 PSMB8 PSMC6 PSMD3 RNF170 RTP5 SIRPA SMCO3 TEPSIN TRIM39 TSPYL1 UBC USP4 ZBTB44 ZKSCAN4 ZNF596
Entrez ID		2079	5687
HPRD ID		09026	04171
Ensembl ID		ENSG00000100632	ENSG00000100902
Uniprot IDs		A0A024R6D4 P84090	A0A140VK44 P60900
PDB IDs		1W9G 2NML 7CNC	4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSG 6MSH 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ
Enriched GO Terms of Interacting Partners?
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