ERCC6 and EIF4A3

Number of citations of the paper that reports this interaction (PubMedID 31722399)
7

Data Source:
BioGRID (pull down)

		ERCC6	EIF4A3
Description		ERCC excision repair 6, chromatin remodeling factor	eukaryotic translation initiation factor 4A3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex Site Of DNA Damage	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity Protein Tyrosine Kinase Activator Activity Sequence-specific DNA Binding Protein-containing Complex Binding Protein N-terminus Binding ATP-dependent Chromatin Remodeler Activity	RNA Binding RNA Helicase Activity MRNA Binding Protein Binding ATP Binding Poly(A) Binding ATP Hydrolysis Activity Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding Translation Regulator Activity
	Biological Process	Single Strand Break Repair DNA Damage Checkpoint Signaling Response To Superoxide Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Chromatin Remodeling Transcription Elongation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Response To Oxidative Stress JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Neurogenesis Neuron Differentiation Neuron Projection Development Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Protein Tyrosine Kinase Activity Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing Associative Learning Response To Organic Cyclic Compound Negative Regulation Of Translation Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Negative Regulation Of Selenocysteine Insertion Sequence Binding Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation	ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 26708285) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		117 interacting genes: ACTR2 ACTR3 ARPC1A ATP5F1C ATP5PO CAVIN1 CCT5 CCT6A CHEK2 CLIC4 COPE CORO1C CSNK2A2 CSNK2B CTSB CUL5 DARS1 ECHS1 EIF3C EIF3D EIF3F EIF3I EIF3L EIF4A3 ELOA ERCC5 ERCC8 FBLN2 FNDC3B FOSL1 FXR1 FYTTD1 GATAD2B GRPEL1 GTF2E2 GTF2I H2BC3 H3C1 H4C1 HDAC1 HDAC2 HNRNPUL2 HSPA5 HSPA9 HTATSF1 IARS2 IDH3G IWS1 LEO1 MBD3 MORC3 MRPL11 MRPL13 MRPL20 MRPL21 MRPL3 MRPL38 MRPL4 MRPL47 MRPL50 MRPL58 MRPS18B MRPS22 MRPS25 MRPS26 MTA1 MTA2 MTA3 NAP1L1 NONO NPLOC4 PAF1 PARP1 PCNA PFN2 PML POLR2A POLR2H PPIA PSMC5 RBBP4 RBBP7 RCC1 RHOG RNF11 RPL10 RPL13 RPL30 RPL39 RPL5 RPS15 RPS15A RPS24 RPS29 RPS6 SAE1 SDHA SENP2 SF3B3 SLC39A7 SNRPD1 SUMO1 SUMO2 SUPT6H TACO1 TP53 TPR UBA2 UBC UBE2I UQCRC1 UQCRQ USP7 XAB2 XPA XRCC5 ZBTB38	35 interacting genes: CARD9 CASC3 CCDC174 CCR6 CDCA7L CNKSR3 CWC22 DDIT4L DDX56 DISC1 DRG2 EHMT2 ERCC6 ESR1 HTR6 LNX1 MAGOH MEOX1 MEOX2 NIF3L1 NXF1 PAX4 PDCD4 PICK1 POLR2G PRMT5 PSMA1 RBM8A REL TRIM27 UPF1 UPF3B VRTN YWHAQ ZXDB
Entrez ID		2074	9775
HPRD ID		00596	06482
Ensembl ID		ENSG00000225830	ENSG00000141543
Uniprot IDs		A8K4Q3 P0DP91 Q03468 Q59FF6	A0A024R8W0 I3L3H2 P38919
PDB IDs		4CVO 6A6I	2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV 6YVH 7A5P
Enriched GO Terms of Interacting Partners?
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