NR2F6 and NR2F2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		NR2F6	NR2F2
Description		nuclear receptor subfamily 2 group F member 6	nuclear receptor subfamily 2 group F member 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Retinoic Acid Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Intracellular Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Neuron Development Anatomical Structure Development Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Female Gonad Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Cell Differentiation Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Anatomical Structure Development Limb Development Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Lymphatic Endothelial Cell Fate Commitment
Pathways		Nuclear Receptor transcription pathway	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Mitochondrial DNA copy number ( 30704525) Night sleep phenotypes ( 27126917)	Adventurousness ( 30643258) Birth weight ( 31043758) Cannabis use ( 27023175) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphangioleiomyomatosis (sporadic) ( 31000673) Metabolite levels ( 23823483) Motion sickness ( 25628336) Optic disc area ( 25631615) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 33547301) Sex hormone-binding globulin levels ( 22829776) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)
Interacting Genes		13 interacting genes: ANGPTL1 BCL11A CBX1 ESR1 NAP1L1 NCOA1 NR2F2 NR3C1 NSD1 RAB8A RARG RXRA THRB	21 interacting genes: BCL11A BCL11B BIK CHD2 EP300 HDAC1 HIPK3 MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 RLBP1 SETD7 SQSTM1 SYCP3 TENT5A TRIM24 TRIP4
Entrez ID		2063	7026
HPRD ID		00583	00139
Ensembl ID		ENSG00000160113	ENSG00000185551
Uniprot IDs		F1D8R3 P10588	F1D8R0 P24468
PDB IDs			3CJW
Enriched GO Terms of Interacting Partners?
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