EPS8 and ADAM22

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		EPS8	ADAM22
Description		epidermal growth factor receptor pathway substrate 8	ADAM metallopeptidase domain 22
Image
GO Annotations	Cellular Component	Plasma Membrane Brush Border Cell Cortex Postsynaptic Density NMDA Selective Glutamate Receptor Complex Growth Cone Vesicle Stereocilium Stereocilium Tip Ruffle Membrane Extracellular Exosome Glutamatergic Synapse	Plasma Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Signaling Adaptor Activity	Metalloendopeptidase Activity Integrin Binding Protein Binding
	Biological Process	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Adult Locomotory Behavior Myelination In Peripheral Nervous System Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	LGI-ADAM interactions
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)	Blood protein levels ( 30072576) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126)
Interacting Genes		63 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR ERBB3 GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN TRIP11 USP6NL XAGE2 XRCC6 ZZZ3	6 interacting genes: APP EPS8 LGI1 RAC2 YWHAB YWHAZ
Entrez ID		2059	53616
HPRD ID		02563	04751
Ensembl ID		ENSG00000151491	ENSG00000008277
Uniprot IDs		B4E3T6 Q12929	Q08AL8 Q9P0K1
PDB IDs		2E8M	3G5C 5Y2Z 5Y31 7CQF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?