EPHB2 and SH2D3C

Number of citations of the paper that reports this interaction (PubMedID 10542222)
30

Data Source:
HPRD (in vitro)

		EPHB2	SH2D3C
Description		EPH receptor B2	SH2 domain containing 3C
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body Receptor Complex Postsynapse Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Cytoplasm Axon Ruffle Membrane
	Molecular Function	Amyloid-beta Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity Identical Protein Binding Protein-containing Complex Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Angiogenesis Urogenital System Development Negative Regulation Of Protein Phosphorylation Positive Regulation Of Immunoglobulin Production Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Or Memory Learning Positive Regulation Of Gene Expression Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Retinal Ganglion Cell Axon Guidance Positive Regulation Of Synaptic Plasticity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Kinase Activity B Cell Activation Inner Ear Morphogenesis Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Commissural Neuron Axon Guidance Postsynaptic Membrane Assembly Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Neuron Projection Retraction Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of NMDA Glutamate Receptor Activity Positive Regulation Of NMDA Glutamate Receptor Activity	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling L1CAM interactions EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Refractive error ( 32231278) Triiodothyronine levels ( 30843173) Triiodothyronine levels and thyroxine levels ( 30843173)	Basophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		40 interacting genes: ABL1 ABL2 ACP1 AFDN AQP1 ARHGEF6 CRK EFNA5 EFNB1 EFNB2 ERBB2 ERF FBXO7 FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MMP2 MMP9 MTMR14 NCK1 PICK1 PLCG1 PTK2 RASA1 RNF186 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 TRIM54 VAV2 VEGFA YES1	17 interacting genes: AR BCAR1 CARD11 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 GOLGA2 KIT MAPK1 MET NEDD9 PTK2B SNCAIP SRC
Entrez ID		2048	10044
HPRD ID		02997	05284
Ensembl ID		ENSG00000133216	ENSG00000095370
Uniprot IDs		B4DSE0 P29323 Q4LE53 Q6NVW1	B4DG32 Q8N5H7
PDB IDs		1B4F 1F0M 2QBX 3ZFM	3T6G
Enriched GO Terms of Interacting Partners?
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