EPHA3 and TPTE

Number of citations of the paper that reports this interaction (PubMedID 28065597)
37

Data Source:
BioGRID (two hybrid)

		EPHA3	TPTE
Description		EPH receptor A3	transmembrane phosphatase with tensin homology
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton Nuclear Membrane Neuron Projection Receptor Complex	Nucleus Cytosol Plasma Membrane Integral Component Of Membrane Cell Projection
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity
	Biological Process	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Kinase Activity Regulation Of GTPase Activity Negative Regulation Of Endocytosis Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Protein Localization To Plasma Membrane	Protein Dephosphorylation Signal Transduction Negative Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Signaling Dephosphorylation Peptidyl-tyrosine Dephosphorylation Phosphatidylinositol Dephosphorylation Cell Motility Regulation Of Protein Kinase B Signaling
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Synthesis of PIPs at the Golgi membrane
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Lateral thalamic nuclei volume ( 34006833) Loneliness (multivariate analysis) ( 27629369) Lung function (FVC) ( 26635082) Orofacial clefts ( 22863734) Periodontitis (Mean PAL) ( 24024966) Post-bronchodilator FEV1 x air pollution (NO2) interaction in childhood asthma ( 31028280) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Tea consumption ( 31046077) Thrombosis ( 26908601) Ventral thalamic nuclei volume ( 34006833) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Weight ( 34074324)	Celiac disease ( 23936387)
Interacting Genes		29 interacting genes: ABL1 ADAM10 CDKN2A CRK CTDSP2 DUSP18 DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 ERBB2 FBXO7 FYN ILKAP MTMR11 PIM1 RBM18 RUFY1 RUFY2 SRC SRPK1 STAT3 STYX TP53 TPTE	11 interacting genes: ADRB2 EPHA1 EPHA2 EPHA3 ERBB3 MEOX2 NTRK1 PDGFRB PTK7 ROR2 TUBB3
Entrez ID		2042	7179
HPRD ID		01555	05064
Ensembl ID		ENSG00000044524	ENSG00000274391
Uniprot IDs		A0A140VJJ0 C9JXA2 P29320 Q6P4R6	P56180
PDB IDs		2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4 4L0P 4P4C 4P5Q 4P5Z 4TWN 4TWO 6IN0
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?