TUBB and PFDN4

Number of citations of the paper that reports this interaction (PubMedID 14634002)
18

Data Source:
HPRD (in vitro)

		TUBB	PFDN4
Description		tubulin beta class I	prefoldin subunit 4
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytosol Cytoskeleton Microtubule Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding	Amyloid-beta Binding Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cellular Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Regulation Of Synapse Organization Spindle Assembly Cell Division	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287) Leftâ€“right brain asymmetry ( 33723403) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Atopic dermatitis ( 23042114) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Creatinine levels ( 31015462) HDL cholesterol levels in HIV infection ( 33109212) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Obesity-related traits ( 23251661)
Interacting Genes		79 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CDH16 CDKN2A CLIP1 CMTM5 CNN1 CREBBP CRIPT DISC1 DPYSL2 DUX4 DYNLL1 EML4 ESR1 FXR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 OGT PFDN4 PLK1 PRKN PTEN RAB8B RACK1 RASSF1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TGM2 TINF2 TPPP TTBK1 TTK TUBA1A UBE3A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19	6 interacting genes: ACTB ERBB3 PFDN2 RFPL3 TUBA4A TUBB
Entrez ID		203068	5203
HPRD ID		01852	05358
Ensembl ID		ENSG00000196230	ENSG00000101132
Uniprot IDs		B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16	Q9NQP4
PDB IDs		3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ	6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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