SMIM14 and SLPI

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SMIM14	SLPI
Description		small integral membrane protein 14	secretory leukocyte peptidase inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Golgi Apparatus Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Blastocyst Hatching	Immune Response Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Modulation Of Process Of Other Organism Negative Regulation Of Viral Genome Replication Innate Immune Response
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Triglyceride levels ( 32203549)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576 28240269) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)
Interacting Genes		5 interacting genes: FATE1 LSM4 SGTA SLPI TMEM42	25 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2
Entrez ID		201895	6590
HPRD ID		14129	00121
Ensembl ID		ENSG00000163683	ENSG00000124107
Uniprot IDs		A0A024R9U4 Q96QK8	P03973
PDB IDs			2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?
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