EIF2B1 and POLE

		EIF2B1	POLE
Description		eukaryotic translation initiation factor 2B subunit alpha	DNA polymerase epsilon, catalytic subunit
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication Leading Strand Elongation Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Replication Proofreading Embryonic Organ Development Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Recycling of eIF2:GDP	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)
Interacting Genes		22 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 POLE RD3 TRIM59 TRIML2 UBE2I	19 interacting genes: ABHD16A EIF2B1 GINS4 MDM2 MMP17 NOS1 PCNA POLA1 POLD4 POLE2 POLE4 RAD17 RAN SCARB1 STK19 TOPBP1 ULK1 VSIG4 XRCC5
Entrez ID		1967	5426
HPRD ID		09458	07177
Ensembl ID		ENSG00000111361	ENSG00000177084
Uniprot IDs		Q14232	Q07864
PDB IDs		3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46	5VBN
Enriched GO Terms of Interacting Partners?
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