DTX3 and PTK6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DTX3	PTK6
Description		deltex E3 ubiquitin ligase 3	protein tyrosine kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Notch Signaling Pathway Protein Ubiquitination	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Projection Development Cell Migration Cell Differentiation ERBB2 Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Innate Immune Response Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Growth Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid
Pathways			SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization Cytoprotection by HMOX1
Drugs			Vandetanib Fostamatinib Zanubrutinib
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Hair shape ( 29220522) Prostate cancer ( 23535732)
Interacting Genes		44 interacting genes: ARF5 BAG3 DTX1 DTX2 EPM2AIP1 FAM90A1 FYN GRB2 MAPK9 NCK2 NFKBID NOTCH2 OSTF1 PARP11 PTK6 RNF141 RNF38 TCEANC TRAF4 TRIP10 UBASH3A UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2W UEVLD USP1 USP2 USP21 XIAP YES1 ZDHHC17 ZMYND19	35 interacting genes: ACTN3 ANKRD55 APP AR CBLB CCDC33 DDX17 DOK1 DTX3 EFHC2 EGFR ERBB2 ERBB3 ERBB4 EXOC5 FCHO1 FGFR1 GAB1 HIF1A KHDRBS1 KHDRBS2 KIAA1217 KIT LINC01139 MEIS2 MET MKRN3 MYOZ3 PITX1 PRDM6 REL SLA STAP2 WASL ZNF341
Entrez ID		196403	5753
HPRD ID		16842	03594
Ensembl ID		ENSG00000178498	ENSG00000101213
Uniprot IDs		A0A024RB96 Q8N9I9	Q13882
PDB IDs			1RJA 2KGT 5D7V 5DA3 5H2U 6CZ2 6CZ3 6CZ4
Enriched GO Terms of Interacting Partners?
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