MEGF8 and HPN

		MEGF8	HPN
Description		multiple EGF like domains 8	hepsin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Integral Component Of Membrane Extracellular Exosome	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Apical Plasma Membrane Nuclear Membrane Neuronal Cell Body Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Serine-type Exopeptidase Activity
	Biological Process	Embryonic Heart Tube Morphogenesis Animal Organ Morphogenesis Tissue Development Regulation Of Gene Expression Embryonic Limb Morphogenesis BMP Signaling Pathway Limb Morphogenesis Cell Migration Involved In Gastrulation Negative Regulation Of Smoothened Signaling Pathway Embryonic Skeletal System Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Epiboly Involved In Gastrulation With Mouth Forming Second Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Coronary Vasculature Development Determination Of Heart Left/right Asymmetry Determination Of Digestive Tract Left/right Asymmetry Craniofacial Suture Morphogenesis Fasciculation Of Sensory Neuron Axon	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Positive Regulation Of Cell Growth Basement Membrane Disassembly Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Transcription Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation
Pathways			MET Receptor Activation Signaling by MST1
Drugs			Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
Diseases
GWAS			C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Liver enzyme levels (alkaline phosphatase) ( 33972514) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum albumin level ( 23022100) Serum total protein level ( 29403010) Triglyceride levels ( 32203549 32154731) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in diabetes ( 31511532)
Interacting Genes		8 interacting genes: ATN1 CACNA1A CCNE1 GFI1B HOXA1 HPN SYT5 URI1	9 interacting genes: BNIP3 BRIP1 EGFR F7 GLP1R HGF MEGF8 SFTPC UPK2
Entrez ID		1954	3249
HPRD ID		10370	00801
Ensembl ID		ENSG00000105429	ENSG00000105707
Uniprot IDs		Q7Z7M0	A0A140VJK9 B7Z1L4 P05981
PDB IDs			1O5E 1O5F 1P57 1Z8G 3T2N 5CE1
Enriched GO Terms of Interacting Partners?
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