CELSR2 and KLF6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		CELSR2	KLF6
Description		cadherin EGF LAG seven-pass G-type receptor 2	Kruppel like factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	G Protein-coupled Receptor Activity Calcium Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Neuron Migration Cilium Movement Regulation Of Transcription, DNA-templated Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway Ventricular System Development Neural Plate Anterior/posterior Regionalization Regulation Of Cell-cell Adhesion Regulation Of Protein Localization Cerebrospinal Fluid Secretion Dendrite Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Cilium Assembly Cell-cell Adhesion	Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549 33730874) Apolipoprotein B levels ( 32203549) Blood protein levels ( 29875488 28240269) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 28270201 19060911 24886709 25961943 26780889 20686565) Coronary artery disease ( 29212778 30104761 33020668) Coronary heart disease ( 21378988) HDL cholesterol ( 30275531 25961943) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) Heel bone mineral density ( 30598549) LDL cholesterol ( 18262040 18179892 18193043 18193044 20864672 19060906 19060910 19060911 30275531 21347282 25961943 26780889 20686565) LDL cholesterol levels ( 32203549 31087446 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 19936222) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease ( 28753643) Low density lipoprotein cholesterol levels ( 30718733 32902719 32154731 30911093 29403010 33339817) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 21909109) Metabolite levels (lipoprotein measures) ( 27005778) Myocardial infarction ( 33532862) Myocardial infarction (early onset) ( 19198609) NHDL cholesterol levels ( 32902719) Parental lifespan ( 30642433) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Response to statin therapy ( 20339536) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 30718733 32902719 30911093 29403010 33339817 30275531)	Asthma (bronchodilator response) ( 23508266) Coronary artery calcification ( 23870195) Diastolic blood pressure ( 27841878) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549 28869591) Height ( 33713608) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Plasma anti-thyroglobulin levels ( 29678681) Red blood cell count ( 32888494)
Interacting Genes		4 interacting genes: GARS1 KLF6 NFATC3 PHF10	16 interacting genes: APOM APP CELSR2 EHMT2 FBL GTF3C1 HDAC3 KLF4 LCOR NOP56 NUFIP1 PNO1 POLA2 SP1 TAF9 TP53
Entrez ID		1952	1316
HPRD ID		05040	03632
Ensembl ID		ENSG00000143126	ENSG00000067082
Uniprot IDs		Q9HCU4	D3GC14 Q99612
PDB IDs
Enriched GO Terms of Interacting Partners?
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