EFNB1 and EPHB1

Number of citations of the paper that reports this interaction (PubMedID 10669731)
45

Data Source:
HPRD (in vivo, in vitro)

		EFNB1	EPHB1
Description		ephrin B1	EPH receptor B1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Raft Synapse Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Early Endosome Membrane Filopodium Tip Neuron Projection Receptor Complex Membrane Raft Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Ephrin Receptor Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Protein-containing Complex Binding
	Biological Process	Neural Crest Cell Migration Cell Adhesion Cell-cell Signaling Axon Guidance Embryonic Pattern Specification T Cell Costimulation Positive Regulation Of T Cell Proliferation Ephrin Receptor Signaling Pathway	Angiogenesis Immunological Synapse Formation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Skeletal Muscle Satellite Cell Activation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Positive Regulation Of Kinase Activity Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Camera-type Eye Morphogenesis Modulation Of Chemical Synaptic Transmission Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Regulation Of Neuron Death Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS			Adult body size ( 32376654) Bitter beverage consumption ( 31046077) Body shape index ( 34021172) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		17 interacting genes: ANKRD46 CAPN10 CUL3 EPHA3 EPHB1 EPHB2 GRIP1 MYC NCK2 PICK1 PTPN13 RGS3 SDCBP SORBS1 SRC TIAM1 YWHAQ	23 interacting genes: AADAC ACP1 ACP3 AMOTL2 CTPS1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GM2A GRB10 GRB2 GTF2E1 MBD4 MRPL3 MTDH NCK1 PCCB PRKCG PXN UQCRC2
Entrez ID		1947	2047
HPRD ID		02072	02790
Ensembl ID		ENSG00000090776	ENSG00000154928
Uniprot IDs		P98172	P54762
PDB IDs		6THG	2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW
Enriched GO Terms of Interacting Partners?
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