AGO3 and BDNF

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		AGO3	BDNF
Description		argonaute RISC catalytic component 3	brain derived neurotrophic factor
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome P-body Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex	Extracellular Region Extracellular Space Cytoplasm Mitochondrion Synaptic Vesicle Nuclear Speck Axon Dendrite Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Endoribonuclease Activity Protein Binding MiRNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving MiRNA-paired MRNA	Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	MRNA Catabolic Process RNA Secondary Structure Unwinding Positive Regulation Of Gene Expression Pre-miRNA Processing Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Regulation Of Stem Cell Proliferation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In Gene Silencing By SiRNA Positive Regulation Of NIK/NF-kappaB Signaling	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Synapse Assembly Peripheral Nervous System Development Memory Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Collateral Sprouting Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Receptor Binding Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5
Drugs			CX-717 Copper Chondroitin sulfate Esketamine
Diseases
GWAS			Adult body size ( 32376654) Alcohol consumption ( 31358974) Apolipoprotein A1 levels ( 32203549) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28552196 29381148 23563607 19079260 26961502 24861553 31453325 28892062 25673413 20935630 29273807 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Brain-derived neurotrophic factor levels ( 33345186) Caffeine consumption from coffee or tea ( 33287642) Childhood body mass index ( 33045005 26604143) Chloride levels ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Coffee consumption (cups per day) ( 25288136) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) Falling risk ( 32999390) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Morning person ( 30696823) Obesity ( 21708048 23563607) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking behavior ( 20418890) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urinary sodium excretion ( 31409800) Waist circumference ( 25673412) Weight ( 28552196 19079260) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: ATP4B ATP6V0D2 BDNF CXCR4 SLC22A2	26 interacting genes: AGO3 APBA3 APP ARHGAP1 CADPS2 CD44 CD59 CPE ESR1 F11R FAM209A GPR152 INPP5K JUNB LRP1 MBTPS1 MBTPS2 MPPED2 NCAM1 NOS3 NTF3 NTF4 NTRK2 PSMC3 RHOU SORT1
Entrez ID		192669	627
HPRD ID		09558	00214
Ensembl ID		ENSG00000126070	ENSG00000176697
Uniprot IDs		B4E1P5 Q9H9G7	A0A0E3SU01 P23560
PDB IDs		5VM9	1B8M 1BND
Enriched GO Terms of Interacting Partners?
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