S1PR1 and HTR1D

Number of citations of the paper that reports this interaction (PubMedID 11854302)
18

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		S1PR1	HTR1D
Description		sphingosine-1-phosphate receptor 1	5-hydroxytryptamine receptor 1D
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Intracellular Membrane-bounded Organelle Membrane Raft	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Binding Sphingosine-1-phosphate Receptor Activity Sphingolipid Binding	G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity Serotonin Binding
	Biological Process	Angiogenesis Blood Vessel Maturation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Sphingosine-1-phosphate Receptor Signaling Pathway Chemotaxis Cell Adhesion G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Brain Development Cell Migration Regulation Of Metabolic Process Transmission Of Nerve Impulse Lamellipodium Assembly Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Leukocyte Chemotaxis Actin Cytoskeleton Reorganization Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Negative Regulation Of Stress Fiber Assembly Heart Trabecula Morphogenesis T Cell Migration	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Intestine Smooth Muscle Contraction Regulation Of Locomotion Vasoconstriction Regulation Of Behavior
Pathways		Lysosphingolipid and LPA receptors Interleukin-4 and Interleukin-13 signaling Potential therapeutics for SARS	Serotonin receptors G alpha (i) signalling events
Drugs		Fingolimod Asfotase alfa Siponimod Ozanimod	Eletriptan Ziprasidone Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Fenfluramine Lisuride Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Almotriptan Naratriptan Rizatriptan Frovatriptan Ergoloid mesylate Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Yohimbine Lofexidine NXN-188 Pizotifen Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Irritable bowel syndrome ( 29673008) Lymphocyte counts ( 29403010 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Sensorimotor dexterity ( 31596458) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31015462) Height ( 28552196 20881960) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: AKT1 APP CAV1 CMSS1 GNAI1 GNAI3 HTR1A HTR1D PDGFRB	3 interacting genes: HTR1A HTR1B S1PR1
Entrez ID		1901	3352
HPRD ID		03578	01636
Ensembl ID		ENSG00000170989	ENSG00000179546
Uniprot IDs		P21453	P28221
PDB IDs		3V2W 3V2Y
Enriched GO Terms of Interacting Partners?
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