RCAN1 and KCNE1

		RCAN1	KCNE1
Description		regulator of calcineurin 1	potassium voltage-gated channel subfamily E regulatory subunit 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Apical Plasma Membrane Z Disc Membrane Raft
	Molecular Function	Nucleic Acid Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Response To Ischemia Response To Oxidative Stress Short-term Memory Calcium-mediated Signaling Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Regulation Of Phosphoprotein Phosphatase Activity Skeletal Muscle Fiber Development Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Sensory Perception Of Sound Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways			Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Dipyridamole	Enflurane Promethazine Miconazole Azimilide
Diseases
GWAS		Cancer ( 29299148) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) Hippocampal volume ( 29274321) L-selectin levels ( 25576479) Long QT syndrome ( 32429735) QT interval ( 30679814 29213071 24952745 31217584)
Interacting Genes		15 interacting genes: APP ATP5PO BTRC CBR3 DSCAM GSK3B IL10RB ITSN1 KCNE1 MAP3K3 MAPK3 PPP3CA SON USP22 UXT	9 interacting genes: ADRB2 CBR3 KCNH2 KCNJ15 KCNQ1 PRKCA RCAN1 TPM3 UBASH3A
Entrez ID		1827	3753
HPRD ID		04226	01442
Ensembl ID		ENSG00000159200	ENSG00000180509
Uniprot IDs		B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9	A7LFK2 A7LFK4 C7S316 P15382 Q6FHJ6
PDB IDs		6UUQ	2K21
Enriched GO Terms of Interacting Partners?
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