DNMT3B and WARS1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		DNMT3B	WARS1
Description		DNA methyltransferase 3 beta	tryptophanyl-tRNA synthetase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding	Tryptophan-tRNA Ligase Activity Protein Binding ATP Binding Kinase Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia DNA Methylation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Ionizing Radiation Positive Regulation Of Gene Expression Response To Activity Response To Caffeine Response To Estradiol Response To Vitamin A Response To Cocaine Positive Regulation Of Neuron Differentiation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Hyperoxia Cellular Response To Dexamethasone Stimulus C-5 Methylation Of Cytosine	Angiogenesis Negative Regulation Of Protein Phosphorylation Translation Tryptophanyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Protein ADP-ribosylation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Angiogenesis
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis	Cytosolic tRNA aminoacylation
Drugs		Decitabine	Tryptophan Tryptophanyl-5'amp Tryptophanamide
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)
Interacting Genes		38 interacting genes: BAZ2A CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18	11 interacting genes: APP CDK2AP2 DCAF13 DNMT3B EEF1A1 LIG4 LINC01554 MDH2 OGT TERF1 UBC
Entrez ID		1789	7453
HPRD ID		04209	01845
Ensembl ID		ENSG00000088305	ENSG00000140105
Uniprot IDs		Q9UBC3	A0A024R6K8 P23381
PDB IDs		3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91	1O5T 1R6T 1R6U 1ULH 2AKE 2AZX 2DR2 2QUH 2QUI 2QUJ 2QUK 5UJI 5UJJ
Enriched GO Terms of Interacting Partners?
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