DYNC1H1 and KATNA1

Number of citations of the paper that reports this interaction (PubMedID 16203747)
54

Data Source:
BioGRID (pull down, affinity chromatography technology)

		DYNC1H1	KATNA1
Description		dynein cytoplasmic 1 heavy chain 1	katanin catalytic subunit A1
Image
GO Annotations	Cellular Component	Extracellular Region Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Filopodium Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm	Spindle Pole Cytoplasm Centrosome Spindle Microtubule Microtubule Cytoskeleton Midbody Mitotic Spindle Pole
	Molecular Function	RNA Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Minus-end-directed Vesicle Transport Along Microtubule Regulation Of Metaphase Plate Congression Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly	Cell Cycle Microtubule Severing Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)	Brain morphology (MOSTest) ( 32665545) Lung cancer ( 27393504) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)
Interacting Genes		29 interacting genes: ASB7 ATP2B3 BRCA1 COX20 DISC1 DUX4 DYNLL1 ECSIT EGFR KATNA1 KATNB1 LINC01554 LMO4 MRE11 MTNR1B NDEL1 PAFAH1B1 PPP2R5C PRKCD PSMB9 RHBDD2 SMAD2 SORBS2 SUMO2 TENT5A TNIK YWHAG YWHAQ ZBTB42	11 interacting genes: APP CLK1 CLU DCAF1 DYNC1H1 DYRK2 ESR1 KATNB1 LIPE OGT PAFAH1B1
Entrez ID		1778	11104
HPRD ID		02524	05986
Ensembl ID		ENSG00000197102	ENSG00000186625
Uniprot IDs		Q14204	A8K7S5 O75449
PDB IDs		2BOR 2BOT 5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A	5ZQL 5ZQM
Enriched GO Terms of Interacting Partners?
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