DLG2 and NLGN2

Number of citations of the paper that reports this interaction (PubMedID 9278515)
214

Data Source:
BioGRID (two hybrid)

		DLG2	NLGN2
Description		discs large MAGUK scaffold protein 2	neuroligin 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Neuromuscular Junction Neuron Projection Perikaryon Juxtaparanode Region Of Axon Postsynaptic Density Membrane Axon Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Inhibitory Synapse Spanning Component Of Membrane Glycinergic Synapse Dopaminergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding Kinase Binding	Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Chemical Synaptic Transmission Embryo Development Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Sensory Perception Of Pain Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Synaptic Vesicle Endocytosis Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Terminal Button Organization Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Potential Cell-cell Adhesion Presynapse Assembly Positive Regulation Of Protein Localization To Synapse Inhibitory Synapse Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Attention function in attention deficit hyperactive disorder ( 26174813) BMI at adiposity rebound ( 31840077) Body fat mass ( 28552196) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronic obstructive pulmonary disease ( 25584925) Chronic periodontitis ( 25008200) Estrogen level change in anastrozole-treated breast cancer ( 32701512) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Migraine without aura ( 28952330) Mild influenza (H1N1) infection ( 26379185) Modic changes ( 30808802) Myopia ( 27182965) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pallidum volume ( 31530798) Parkinson's disease ( 25064009 32201043 28892059 28011712 17052657 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Phospholipid levels (plasma) ( 22359512) Pork consumption ( 32066663) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein quantitative trait loci ( 18464913) Putamen volume ( 29147026) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Schizophrenia ( 30285260) Schizophrenia x sex interaction ( 34099189) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical brain region volumes ( 25607358) Trunk fat mass ( 28552196) Type 2 diabetes ( 31049640) Urate levels in overweight individuals ( 25811787) Weight ( 28552196) Wilms tumor ( 22544364)	Refractive error ( 32231278) Uterine fibroids ( 30194396) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		53 interacting genes: ABCA1 ALK AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VTN WNT3A	9 interacting genes: DLG2 DLG3 DLG4 DNAH9 MDGA1 NRXN1 NRXN2 NRXN3 PATJ
Entrez ID		1740	57555
HPRD ID		04663	07348
Ensembl ID		ENSG00000150672	ENSG00000169992
Uniprot IDs		B7Z2T4 Q15700	Q8NFZ4
PDB IDs		2BYG 2HE2	5XEQ
Enriched GO Terms of Interacting Partners?
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