DHODH and TMED10

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		DHODH	TMED10
Description		dihydroorotate dehydrogenase (quinone)	transmembrane p24 trafficking protein 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Integral Component Of Membrane Neuronal Cell Body	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Gamma-secretase Complex
	Molecular Function	Dihydroorotate Dehydrogenase Activity Protein Binding FMN Binding Ubiquinone Binding	Protein Binding Protein Transmembrane Transporter Activity Syntaxin Binding Protein-containing Complex Binding
	Biological Process	'de Novo' Pyrimidine Nucleobase Biosynthetic Process Female Pregnancy Lactation Pyrimidine Ribonucleotide Biosynthetic Process Response To Xenobiotic Stimulus Response To Caffeine Response To Starvation Positive Regulation Of Apoptotic Process 'de Novo' UMP Biosynthetic Process Regulation Of Mitochondrial Fission Response To L-arginine	Kidney Development Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Positive Regulation Of Interleukin-1 Production Vesicle Cargo Loading COPI-coated Vesicle Budding Response To Alkaloid Regulated Exocytosis Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Positive Regulation Of Protein Secretion Protein Transmembrane Transport Protein Localization To ERGIC Cytosol To ERGIC Protein Transport Regulation Of Amyloid-beta Formation Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Pathways		Pyrimidine biosynthesis	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Leflunomide Atovaquone Orotic acid Capric dimethyl amine oxide Flavin mononucleotide Brequinar Analog Brequinar Dodecyldimethylamine N-oxide 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone 5-Carbamoyl-1,1':4',1''-terphenyl-3-carboxylic acid SC12267 Manitimus (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide 3,6,9,12,15-PENTAOXATRICOSAN-1-OL Teriflunomide
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bone mineral density (hip) ( 30172743) Fibrinogen levels ( 28107422) Hand grip strength ( 29691431) LDL cholesterol levels in HIV infection ( 33109212) Low density lipoprotein cholesterol levels ( 29403010) Morning person ( 30696823) Number of sexual partners ( 30643258) Total cholesterol levels ( 29403010 33339817)	Coronary artery disease ( 32469254) Heel bone mineral density ( 30598549) Height ( 19343178) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: MT2A RNF19B TMED10 TTPA	22 interacting genes: APH1A ARCN1 ARF1 CDC42 COPA COPB1 COPB2 COPE COPG1 COPG2 COPZ1 DHODH FBXO7 GORASP2 NCSTN NPC2 NPSR1 PSENEN RGS6 SEC23B SLC13A1 TMED2
Entrez ID		1723	10972
HPRD ID		00521	12013
Ensembl ID		ENSG00000102967	ENSG00000170348
Uniprot IDs		Q02127	A0A024R6I3 P49755
PDB IDs		1D3G 1D3H 2B0M 2BXV 2FPT 2FPV 2FPY 2FQI 2PRH 2PRL 2PRM 2WV8 3F1Q 3FJ6 3FJL 3G0U 3G0X 3KVJ 3KVK 3KVL 3KVM 3U2O 3W7R 3ZWS 3ZWT 4IGH 4JGD 4JS3 4JTS 4JTT 4JTU 4LS0 4LS1 4LS2 4OQV 4RK8 4RKA 4RLI 4RR4 4YLW 4ZL1 4ZMG 5H2Z 5H73 5HIN 5HQE 5K9C 5K9D 5MUT 5MVC 5MVD 5TCE 5ZF4 5ZF7 5ZF8 5ZF9 5ZFA 5ZFB 6CJF 6CJG 6ET4 6FMD 6GK0 6IDJ 6J3B 6J3C 6JMD 6JME 6LP6 6LP7 6LP8 6LZL 6M2B 6OC0 6OC1 6QU7 6SYP 6VND 7K2U
Enriched GO Terms of Interacting Partners?
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