SPTSSA and AKAP6

		SPTSSA	AKAP6
Description		serine palmitoyltransferase small subunit A	A-kinase anchoring protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Serine C-palmitoyltransferase Complex	Nuclear Envelope Cytoplasm Caveola Junctional Sarcoplasmic Reticulum Membrane Intercalated Disc Sarcoplasmic Reticulum T-tubule Nuclear Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding	Protein Binding Adenylate Cyclase Binding Protein Kinase A Regulatory Subunit Binding Protein-membrane Adaptor Activity Transmembrane Transporter Binding Protein Kinase A Binding Molecular Adaptor Activity
	Biological Process	Protein Localization Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process	Action Potential Protein Targeting Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum CAMP-mediated Signaling Positive Regulation Of Cell Growth Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Membrane Repolarization Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To CAMP Cellular Response To Cytokine Stimulus Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Intraocular pressure ( 29785010 31959993)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 21079607) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Creatine kinase levels ( 29403010) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (environmentalism) ( 22566634) Fasting blood insulin (BMI interaction) ( 22581228) General cognitive ability ( 29844566) Glioma ( 28346443) HDL cholesterol levels ( 32203549) Intelligence (MTAG) ( 29326435) Night sleep phenotypes ( 27126917) Non-glioblastoma glioma ( 28346443) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 30297969) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Walking pace ( 33128006)
Interacting Genes		10 interacting genes: AKAP6 BBS2 CYSRT1 GET1 GLP1R HERPUD2 RHBDL1 TMEM31 TUBB3 VKORC1	19 interacting genes: BIRC5 CALM1 CDC5L DISC1 DTNBP1 FUT3 GEMIN2 MAGEA6 PABPN1 PDE4D PGC PPP2CA PRKAR2A PTPRM RYR1 RYR2 SLC8A1 SPTSSA SSTR1
Entrez ID		171546	9472
HPRD ID		16610	05257
Ensembl ID		ENSG00000165389	ENSG00000151320
Uniprot IDs		Q969W0	B2RP22 Q13023
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q
Enriched GO Terms of Interacting Partners?
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