DEFA3 and DEFA1

Number of citations of the paper that reports this interaction (PubMedID 2997278)
345

Data Source:
HPRD (in vitro)

		DEFA3	DEFA1
Description		defensin alpha 3	defensin alpha 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Molecular_function Protein Homodimerization Activity	Protein Binding
	Biological Process	Innate Immune Response In Mucosa Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Membrane Disruption In Other Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide	Innate Immune Response In Mucosa Chemotaxis Immune Response T Cell Chemotaxis Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Defense Response To Protozoan Pore Formation In Membrane Of Other Organism During Symbiotic Interaction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Membrane Disruption In Other Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide
Pathways		Defensins Alpha-defensins	Defensins Alpha-defensins Neutrophil degranulation
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Dental caries (decayed and filled deciduous teeth) ( 31533690) Monocyte percentage of white cells ( 32888494)	Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chromium levels ( 26025379) Dental caries (decayed and filled deciduous teeth) ( 31533690) Endometriosis ( 28333195) Periodontitis (PAL4Q3) ( 24024966)
Interacting Genes		1 interacting genes: DEFA1	6 interacting genes: C1QB DEFA3 GSK3B PFDN1 SERPINF2 UBQLN2
Entrez ID		1668	1667
HPRD ID		05159	00499
Ensembl ID		ENSG00000239839	ENSG00000206047
Uniprot IDs		P59666 Q6EZE9	P59665
PDB IDs		1DFN 1ZMH 1ZMI 1ZMK 2PM4 2PM5	2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF
Enriched GO Terms of Interacting Partners?
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