TLE5 and SMARCD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TLE5	SMARCD1
Description		TLE family member 5, transcriptional modulator	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex	Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle NpBAF Complex NBAF Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding	Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Multicellular Organism Development Animal Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Chromatin-mediated Maintenance Of Transcription Cellular Response To Fatty Acid
Pathways		Repression of WNT target genes	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS			Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		370 interacting genes: ABI2 AEN AGR2 AKAP8L AMH ANAPC11 ANKRD11 AR ARHGAP32 ARX ASB3 ATN1 ATP6V0D1 BAG4 BAHD1 BCL6 BHLHE40 BIRC7 BPIFA1 BYSL C10orf55 C11orf1 C14orf119 C19orf54 C1orf109 C1orf216 C1orf94 C2CD6 C7orf57 CABP2 CABP4 CABP5 CALCOCO2 CAPN1 CARD9 CCDC120 CCDC57 CCL7 CCNJL CCNK CCNO CFAP206 CIB3 CLIC3 CLIP3 CNFN COA7 CPSF7 CRACR2A CRX CSNK2A1 CSTF2 CSTF2T CT55 CTBP2 CYSRT1 DAZAP2 DCUN1D1 DDX6 DGCR6 DIP2A DMRT2 DMRT3 DMRTB1 DNMT3L DOK6 DVL2 DVL3 DYDC1 EAF1 EAF2 EFEMP2 EFHC1 EIF1AD EIF4E2 ERF EXOSC5 EYA2 FAM124A FAM124B FAM168B FAM214B FAM217B FAM90A1 FANCG FBF1 FBLN1 FCHSD2 FHL3 FOSB FOXD2 FOXN1 FOXP2 FRS3 FSD2 FXR1 FXR2 GABARAP GATA1 GCC1 GEM GFAP GFI1B GIGYF1 GLIS2 GLRX3 GOLGA2 GOLGA6L9 GORASP2 GPANK1 GPATCH2L GRAP2 GRB2 GRN GTF2E1 GYS1 HCN2 HDAC4 HDHD3 HELT HEXIM2 HGS HHEX HMGB1 HNF1A HNRNPF HNRNPH2 HNRNPK HNRNPLL HOMEZ HOXA1 HOXB5 HOXC8 HOXC9 IKZF3 INO80B INO80E INPP5J IRX2 IRX6 KANK2 KDM1A KIFC3 KLF1 KLF4 KLHDC7B KRT13 KRT15 KRT31 KRT34 KRT35 KRT40 KRTAP10-11 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 L3MBTL2 LDLR LDOC1 LENG8 LHX3 LINC00526 LMO1 LMO2 LMO4 LSM2 LZTS2 MAGOHB MAPK1 MAPK14 MAPRE3 MBNL1 MCRS1 MDFI MED12L MED25 MED31 MED4 MEIS3 MFAP1 MIA2 MIIP MKRN3 MLH1 MLLT6 MLX MORF4L1 MORF4L2 MSS51 MSX1 MSX2 MTUS2 MVP MYF5 MYH7B MYO15B MYOG NAB2 NAF1 NBPF19 NCDN NDOR1 NDUFB7 NEK6 NLGN3 NOTCH2NLA NTAQ1 NUDT22 NUTF2 NUTM1 OLIG3 OSGIN1 OXER1 P4HA3 PARVG PATZ1 PAX8 PAX9 PCBP1 PCSK5 PFDN5 PHF1 PHKB PICK1 PITX1 PITX2 PLAGL1 POLR1C POU2F1 PPP1R16A PPP1R16B PRDM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRKAB2 PROP1 PRPF31 PRR3 PRR35 PSMB1 PSMB4 PSMF1 PTRH2 QARS1 RAD51D RBM10 RBPMS REL RELA RFX6 RHOXF2 RIBC1 RIMBP3 RIPPLY1 RNF31 RORB RPL18A RUNX1 RUSC1 SAT1 SCNM1 SDCBP SERTAD3 SET SF3B4 SH2B2 SH3GL3 SHFL SHISA6 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SMAD4 SMARCB1 SMARCD1 SNCAIP SNRPA SNRPC SOHLH1 SOX5 SPATA25 SPG21 SRPK2 SSC4D STK16 STX11 SUFU SUPT5H TBX3 TBX6 TCEANC TCF4 TCF7L2 TEAD4 TENT5B TEX37 TFAP2D THAP7 TIGD3 TMCC2 TNS2 TOX3 TRAF1 TRAF2 TRIB3 TRIM26 TRIM27 TRIM41 TRIP6 TRMT2A TSC1 TSC22D4 TSEN15 TSGA10 TSGA10IP TSSK3 TTC23 U2AF2 UBAP2 UBE2H UBL5 UBXN11 USP2 USP54 VEZF1 VGLL1 VIM VPS37B VPS37C YPEL3 YTHDF1 ZBTB16 ZBTB24 ZBTB47 ZFHX3 ZGPAT ZIC1 ZMYND12 ZNF330 ZNF34 ZNF383 ZNF408 ZNF414 ZNF417 ZNF467 ZNF48 ZNF503 ZNF524 ZNF576 ZNF688 ZNF792 ZNF835 ZRANB1	157 interacting genes: ABI1 ABI2 ABI3 ADAT2 ANKRD23 ANKRD49 ANKS1A ANP32B APOA5 AR ARMC10 ARRDC3 BCAS2 BEND5 BEX3 BHLHB9 BLOC1S5 BRWD1 C19orf54 C1orf109 C4BPA CALCOCO2 CCDC102B CCDC197 CCDC33 CCDC85B CDC5L CDR2 CDSN CDX2 CEACAM6 CHFR CHN2 CLNK COG6 COL1A2 CORO1A CUEDC1 CYSRT1 DCTN2 DISC1 EGFL7 EIF4G1 ESR1 ESS2 FAM136A FAM161A FBXO7 FEZ1 FOS FUS GATA1 GCC1 GIGYF1 GINS3 GOLGA6L9 GRAMD4 HES6 HNRNPC HOMEZ HOXD3 HSF2BP HSPB1 IGKC IKBIP IKZF3 INSC IQCB1 JUN KATNBL1 KDM1A KEAP1 KIAA0753 KLF1 KMT5B KRT15 KRT16 KRT18 KRT27 KRT31 KRT34 KRT37 KRT38 KRT75 LDB2 LDOC1 LZTS2 MAGEA2 MAGEA2B MAGEA6 MED4 MKRN3 MTNR1B MTUS2 NAB2 NECAB2 NELFA NME1 NONO NR1H4 NR3C1 NUCB2 NUDT16L1 NUTM1 OGT PACSIN3 PAICS PBX4 PCBD1 PGR PICK1 PIH1D1 PKNOX2 PLAGL2 PPM1J PRDX1 PRMT6 PSTPIP1 RIF1 RORB RPS29 SCARA5 SCHIP1 SCNM1 SERTAD3 SHISA6 SMARCB1 SMUG1 SNF8 SPSB2 STH STMN3 SYCE1L TCP10L THOC7 TLE5 TNIP2 TP53 TRIM27 TRIM54 TRIM72 USHBP1 USP54 VPS37B WASHC1 WWP2 YJU2B YWHAG ZC2HC1C ZMAT5 ZMYND12 ZNF417 ZNF438 ZNF511 ZNF629 ZNF655 ZNF69
Entrez ID		166	6602
HPRD ID		02556	03438
Ensembl ID		ENSG00000104964	ENSG00000066117
Uniprot IDs		Q08117 Q8WY48	Q96GM5
PDB IDs			6LTH 6LTJ
Enriched GO Terms of Interacting Partners?
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