DDIT3 and RPS3

Number of citations of the paper that reports this interaction (PubMedID 29371697)
12

Data Source:
BioGRID (protein complementation assay)

		DDIT3	RPS3
Description		DNA damage inducible transcript 3	ribosomal protein S3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Late Endosome Cytosol Protein-DNA Complex CHOP-C/EBP Complex CHOP-ATF4 Complex CHOP-ATF3 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Cytosol Ribosome Polysome Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Ruffle Membrane Extracellular Exosome NF-kappaB Complex Mitotic Spindle Ribonucleoprotein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding CAMP Response Element Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Protein Heterodimerization Activity Transcription Regulator Inhibitor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding RNA Binding MRNA Binding Structural Constituent Of Ribosome DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Microtubule Binding Tubulin Binding DNA N-glycosylase Activity Enzyme Binding Kinase Binding Protein Kinase Binding Hsp70 Protein Binding Oxidized Purine DNA Binding Oxidized Pyrimidine DNA Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Protein Kinase A Binding Iron-sulfur Cluster Binding Hsp90 Protein Binding Small Ribosomal Subunit RRNA Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Maturation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus ER Overload Response Response To Unfolded Protein Cell Cycle Sensory Perception Of Sound Anterior/posterior Axis Specification Regulation Of Autophagy Wnt Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-8 Production Negative Regulation Of CREB Transcription Factor Activity Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Response To Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cell Redox Homeostasis Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cytoplasmic Translation DNA Repair Translation Translational Initiation Apoptotic Process Cellular Response To DNA Damage Stimulus Chromosome Segregation Positive Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Interleukin-2 Production Cellular Response To Reactive Oxygen Species Positive Regulation Of Activated T Cell Proliferation DNA Damage Response, Detection Of DNA Damage Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Negative Regulation Of DNA Repair Positive Regulation Of DNA Repair Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Spindle Assembly Cell Division Response To TNF Agonist Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of DNA N-glycosylase Activity Positive Regulation Of Base-excision Repair Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Interacting Genes		69 interacting genes: AMOTL2 ATF2 ATF3 ATF4 ATPAF2 BACH1 BACH2 BATF BATF2 BATF3 CCDC153 CDK6 CEBPA CEBPB CEBPE CEBPG CRACR2A CREB3 CREB3L1 CREBL2 CSNK2A1 DBP DGCR2 DNMT3L EMSY EP300 EPAS1 F2 FOS FOSL1 FOSL2 GIMAP6 GIPC1 GP1BA HOXA5 HSD17B14 IKBKG JDP2 JUN JUNB JUND KPNA2 LMO2 LNX1 MAFF MAFG MAPK14 MCMBP NFE2L2 NFIL3 PCM1 PICALM POLR1D RAI1 RPS3 RPS3A SNAPC5 SPOP SRA1 SSX3 TEDC1 TNFSF12 TRIB3 TXN2 TXNDC2 VPS37C ZBTB25 ZC3H14 ZSCAN31	22 interacting genes: ATP6V0D2 CCT2 CSNK2A1 DDIT3 DUX4 FOLH1 HSP90AA1 IL7R LTV1 MDM2 NDRG1 NFKB1 OGT PDE2A PTEN RELA RPL9 SUMO1 SUMO2 UBC WBP2 YWHAQ
Entrez ID		1649	6188
HPRD ID		00529	10941
Ensembl ID		ENSG00000175197	ENSG00000149273
Uniprot IDs		P35638 Q53YD1	P23396
PDB IDs			1WH9 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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