DCN and COL4A4

Number of citations of the paper that reports this interaction (PubMedID 10382266)
40

Data Source:
HPRD (in vivo)

		DCN	COL4A4
Description		decorin	collagen type IV alpha 4 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VI Trimer Extracellular Space Golgi Lumen Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	RNA Binding Protein Binding Collagen Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein N-terminus Binding Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Kidney Development Placenta Development Skeletal Muscle Tissue Development Aging Response To Mechanical Stimulus Animal Organ Morphogenesis Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Macroautophagy Negative Regulation Of Angiogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Response To Lipopolysaccharide Wound Healing Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Fission Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Extracellular Matrix Organization Glomerular Basement Membrane Development
Pathways		Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs			TRC093
Diseases
GWAS		Blood protein levels ( 30072576) Central corneal thickness ( 32528159 29760442) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998) Refractive error ( 32231278) Sudden cardiac arrest ( 21658281)	Birth weight ( 31043758) Body mass index ( 28270201 25673413) Coronary artery disease ( 29212778) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Macular thickness ( 30535121) Systolic blood pressure ( 30578418) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		30 interacting genes: AHSG BRCA1 C1QA CCN4 COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF	13 interacting genes: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 MTDH OSM SAA1 SERPINE2 TGFBI
Entrez ID		1634	1286
HPRD ID		00501	00360
Ensembl ID		ENSG00000011465	ENSG00000081052
Uniprot IDs		A0A024RBG6 P07585 Q6FH10	P53420
PDB IDs			5NB1
Enriched GO Terms of Interacting Partners?
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