CYP17A1 and ATP5F1E

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CYP17A1	ATP5F1E
Description		cytochrome P450 family 17 subfamily A member 1	ATP synthase F1 subunit epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Axon Neuronal Cell Body	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Sector F(1) Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix
	Molecular Function	Steroid 17-alpha-monooxygenase Activity Iron Ion Binding Oxygen Binding Heme Binding 17-alpha-hydroxyprogesterone Aldolase Activity	Protein Binding Hydrolase Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	Steroid Biosynthetic Process Androgen Biosynthetic Process Glucocorticoid Biosynthetic Process Sex Differentiation Steroid Metabolic Process Hormone Biosynthetic Process Progesterone Metabolic Process	Mitochondrial ATP Synthesis Coupled Proton Transport
Pathways		Androgen biosynthesis Glucocorticoid biosynthesis Defective CYP17A1 causes AH5	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs		NADH Progesterone Spironolactone Ketoconazole Abiraterone Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758) Blood pressure ( 21572416 24001895 21909110) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 26965516) Coronary artery disease ( 32469254 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878 28739976 27618452 25249183) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hip circumference ( 25673412) Hypertension ( 31879980 25249183 30487518) Mean arterial pressure ( 26390057 27618448 30487518) Microalbuminuria ( 26631737) Myocardial infarction ( 33532862 26343387) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Pulse pressure ( 27841878 28739976 30487518) Schizophrenia ( 25056061 29483656 23974872) Sodium levels ( 29403010) Systolic blood pressure ( 26390057 27736895 28135244 19430479 19430483 27841878 21909115 28739976 27618447 27618452 25249183 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Waist circumference ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: APC ATP5F1E BARX1 CDO1 CHEK2 CYB5A ERBB2 FZR1 HSP90AB1 IGF1R POR PTPRJ RPAIN STK11 TIGD7	3 interacting genes: AGTRAP ATP5F1D CYP17A1
Entrez ID		1586	514
HPRD ID		01944	05856
Ensembl ID		ENSG00000148795	ENSG00000124172
Uniprot IDs		P05093 Q1HB44	P56381
PDB IDs		2C17 3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY 4NKZ 5IRQ 5IRV 5UYS 6CHI 6CIR 6CIZ
Enriched GO Terms of Interacting Partners?
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