CCDC50 and MAVS

Number of citations of the paper that reports this interaction (PubMedID 32612200)
8

Data Source:
BioGRID (pull down)

		CCDC50	MAVS
Description		coiled-coil domain containing 50	mitochondrial antiviral signaling protein
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Protein Kinase Binding Signaling Adaptor Activity CARD Domain Binding
	Biological Process	Sensory Perception Of Sound	Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Signal Transduction Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 23562540) Lung cancer in never smokers ( 28604730)	Platelet distribution width ( 32888494)
Interacting Genes		14 interacting genes: ARRDC3 DDX58 HNRNPA1 IFIH1 MAP1LC3B MAVS NPHP3 RIPK1 RNF8 RPS3A SH3GL1 STING1 TNFAIP3 UBC	24 interacting genes: ABL1 CCDC50 DDX3X DDX58 FASTKD5 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP1LC3A MAP3K7 OAS3 OTUD4 RIPK2 RNF115 RNF34 RNF5 SMURF2 STAT1 TBK1 TICAM1 TRAF6 UBE4A
Entrez ID		152137	57506
HPRD ID		06463	13847
Ensembl ID		ENSG00000152492	ENSG00000088888
Uniprot IDs		Q8IVM0	Q7Z434
PDB IDs		6LAN	2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK
Enriched GO Terms of Interacting Partners?
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