CTSW and RICTOR

		CTSW	RICTOR
Description		cathepsin W	RPTOR independent companion of MTOR complex 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Membrane Platelet Dense Granule Lumen	Cytosol TORC2 Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity	Protein Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Immune Response Proteolysis Involved In Cellular Protein Catabolic Process	Positive Regulation Of Endothelial Cell Proliferation Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation TORC2 Signaling Regulation Of GTPase Activity Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Cell Polarity
Pathways		Platelet degranulation	PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Inflammatory bowel disease ( 23128233) Monocyte count ( 32888494)	Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)
Interacting Genes		3 interacting genes: CREB3 NPC2 RICTOR	20 interacting genes: ANXA10 C5orf51 CHUK CTSW CUL1 EIF4EBP1 GSK3A GSK3B IFT20 IKBKB ILK MROH2B MTOR PHKB PLCXD3 PLK1 SGK1 SIAH1 SIRT1 USP9X
Entrez ID		1521	253260
HPRD ID		03840	10682
Ensembl ID		ENSG00000172543	ENSG00000164327
Uniprot IDs		P56202	Q6R327
PDB IDs			5ZCS 6ZWM 6ZWO
Enriched GO Terms of Interacting Partners?
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