ZNF558 and GSDMD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZNF558	GSDMD
Description		zinc finger protein 558	gasdermin D
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Extracellular Region Extracellular Space Nucleoplasm Cytosol Plasma Membrane Integral Component Of Membrane Specific Granule Lumen NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Biological_process	Inflammatory Response Cellular Response To Extracellular Stimulus Positive Regulation Of Interleukin-1 Beta Production Pore Formation In Membrane Of Other Organism Defense Response To Bacterium Innate Immune Response Pore Complex Assembly Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Pyroptosis
Pathways		Generic Transcription Pathway	Release of apoptotic factors from the mitochondria Interleukin-1 processing Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Monocyte count ( 32888494) Schizophrenia ( 31268507)
Interacting Genes		12 interacting genes: APOE CLK2 CSNK2A1 EFEMP2 EIF1AD EXOSC5 GSDMD HEXIM2 LZIC MAD2L2 MFAP1 UBTFL1	8 interacting genes: ASPG KCTD6 MEOX2 MFHAS1 PSMA1 ZBTB33 ZNF426 ZNF558
Entrez ID		148156	79792
HPRD ID		15841	11014
Ensembl ID		ENSG00000167785	ENSG00000104518
Uniprot IDs		Q96NG5	P57764
PDB IDs			5NH1 5WQT 6AO4 6KN0 6N9O
Enriched GO Terms of Interacting Partners?
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