CCBE1 and COPS6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CCBE1	COPS6
Description		collagen and calcium binding EGF domains 1	COP9 signalosome subunit 6
Image		No pdb structure
GO Annotations	Cellular Component	Collagen Trimer Extracellular Space Extracellular Matrix	Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Calcium Ion Binding Protein Binding Collagen Binding	Protein Binding Metallopeptidase Activity Isopeptidase Activity
	Biological Process	Lymphangiogenesis Sprouting Angiogenesis Respiratory System Process Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Processing Lung Development Positive Regulation Of Angiogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Lymphangiogenesis	Protein Deneddylation
Pathways			DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Major depressive disorder ( 23857890) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) PR interval ( 32439900) Pre-treatment viral load in HIV-1 infection ( 31219150) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189)	Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: CEP55 COPS6 FBXO7 FXR1 INCA1 KLHL12 KRT27 KRT36 LNX1 SIAH2 STX11 TOX4	94 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS7B COPS8 COPS9 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHANK3 SHC3 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24
Entrez ID		147372	10980
HPRD ID		08703	16735
Ensembl ID		ENSG00000183287	ENSG00000168090
Uniprot IDs		Q6UXH8	Q7L5N1
PDB IDs			4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I
Enriched GO Terms of Interacting Partners?
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