IL34 and PTPRZ1

Number of citations of the paper that reports this interaction (PubMedID 23744080)
56

Data Source:
BioGRID (pull down)

		IL34	PTPRZ1
Description		interleukin 34	protein tyrosine phosphatase receptor type Z1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Plasma Membrane Synapse Perineuronal Net
	Molecular Function	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Inflammatory Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Interleukin-34-mediated Signaling Pathway Microglial Cell Proliferation Positive Regulation Of Macrophage Proliferation	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Axonogenesis Central Nervous System Development Learning Or Memory Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation
Pathways		Other interleukin signaling	Signaling by ALK Other interleukin signaling
Drugs
Diseases
GWAS		Alzheimer's disease ( 34099642) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cerebrospinal P-tau181p levels ( 28247064) Diffuse cutaneous systemic sclerosis ( 29293537) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Intraocular pressure ( 29785010 30054594) Malaria ( 31844061)	Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)
Interacting Genes		3 interacting genes: ATXN1 LCE1F PTPRZ1	16 interacting genes: AASS ADD2 ALK ARHGAP35 BMP1 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B NMB PTN PTPRF TNR
Entrez ID		146433	5803
HPRD ID		14582	01481
Ensembl ID		ENSG00000157368	ENSG00000106278
Uniprot IDs		A0A024QZ87 Q6ZMJ4	B4DFE7 P23471
PDB IDs		4DKC 4DKD 4DKE 4DKF	3JXF 3S97 5AWX 5H08
Enriched GO Terms of Interacting Partners?
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