PIWIL4 and DICER1

Number of citations of the paper that reports this interaction (PubMedID 14749716)
83

Data Source:
HPRD (two hybrid, in vitro)

		PIWIL4	DICER1
Description		piwi like RNA-mediated gene silencing 4	dicer 1, ribonuclease III
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm P Granule PiP-body	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol RISC Complex Dendrite Growth Cone ARC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome RISC-loading Complex
	Molecular Function	Endoribonuclease Activity PiRNA Binding	DNA Binding RNA Binding Double-stranded RNA Binding Helicase Activity Endoribonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding Protein Domain Specific Binding SiRNA Binding Metal Ion Binding Pre-miRNA Binding
	Biological Process	Regulation Of Translation Spermatogenesis Negative Regulation Of Transposition Epithelial Structure Maintenance Cell Differentiation Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation Meiotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Schwann Cell Differentiation TRNA Catabolic Process Nerve Development Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Negative Regulation Of Tumor Necrosis Factor Production Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference SiRNA Loading Onto RISC Involved In RNA Interference Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Conversion Of Ds SiRNA To Ss SiRNA NIK/NF-kappaB Signaling Neuron Projection Morphogenesis RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		PIWI-interacting RNA (piRNA) biogenesis	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptoms (maternal expressed emotions interaction) ( 18846501) Chromium levels ( 26025379) Colorectal cancer ( 29228715) Mood disorder and prion disease ( 25897833) Mood disorder in prion disease ( 25897833) Small cell lung carcinoma ( 28604730)	Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549 28869591) Metabolite levels ( 23823483) Nose size ( 27182965) Plasma anti-thyroid peroxidase levels ( 29678681) Response to statin therapy ( 20339536)
Interacting Genes		1 interacting genes: DICER1	12 interacting genes: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2 TRIM25
Entrez ID		143689	23405
HPRD ID		11435	05875
Ensembl ID		ENSG00000134627	ENSG00000100697
Uniprot IDs		A0A140VKG8 Q7Z3Z4	Q9UPY3
PDB IDs			2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA 4WYQ 5ZAK 5ZAL 5ZAM
Enriched GO Terms of Interacting Partners?
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