MIB2 and BCL10

Number of citations of the paper that reports this interaction (PubMedID 21896478)
24

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		MIB2	BCL10
Description		MIB E3 ubiquitin protein ligase 2	BCL10 immune signaling adaptor
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Early Endosome Cytosol	Immunological Synapse Polkadots Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Protease Binding Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Kinase Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Kinase B Binding Protein Self-association Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding General Transcription Initiation Factor Binding
	Biological Process	Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	B Cell Apoptotic Process Neural Tube Closure Toll-like Receptor Signaling Pathway Adaptive Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Cellular Defense Response I-kappaB Kinase/NF-kappaB Signaling Cell Death Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Antifungal Innate Immune Response T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Body mass index ( 26426971) Height ( 31562340) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295)	Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)
Interacting Genes		13 interacting genes: ACTA1 ACTC1 BCL10 CYLD DNAH7 GRIN2B JAG2 PUSL1 SRPK2 TBK1 UBE2D2 UBE2N UBE2U	46 interacting genes: AKT1 ANP32B ATM BAAT BIRC3 CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SLC9A3R1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1
Entrez ID		142678	8915
HPRD ID		15905	04625
Ensembl ID		ENSG00000197530	ENSG00000142867
Uniprot IDs		Q96AX9	A0A087WWW9 A2TDT2 O95999
PDB IDs			2MB9 6BZE 6GK2
Enriched GO Terms of Interacting Partners?
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