KRT72 and SP7

		KRT72	SP7
Description		keratin 72	Sp7 transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament Extracellular Exosome	Chromatin Nucleus Cytoplasm
	Molecular Function	Molecular_function Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding DEAD/H-box RNA Helicase Binding Metal Ion Binding
	Biological Process	Biological_process	Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Positive Regulation Of Stem Cell Differentiation
Pathways		Keratinization Formation of the cornified envelope	RUNX2 regulates osteoblast differentiation
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 30498476)	Apolipoprotein A1 levels ( 32203549) Bone mineral density (spine) ( 19079262 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hypospadias (moderate to severe) ( 31856834) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 22504420) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Serum alkaline phosphatase levels ( 33547301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		27 interacting genes: BCDIN3D BLOC1S6 HSPB1 KRT13 KRT14 KRT15 KRT16 KRT17 KRT18 KRT19 KRT20 KRT24 KRT25 KRT27 KRT31 KRT32 KRT33B KRT35 KRT38 KRT40 KRT74 KRT78 KRT80 LARP4 MYL6B SP7 TAMALIN	9 interacting genes: CBL CBLB FAM124B FBXW7 GAS8 KRT72 MAPK14 QARS1 TRIM62
Entrez ID		140807	121340
HPRD ID		09746	05971
Ensembl ID		ENSG00000170486	ENSG00000170374
Uniprot IDs		Q14CN4	A0A024RAY8 Q8TDD2
PDB IDs
Enriched GO Terms of Interacting Partners?
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