COL16A1 and ZEB2

		COL16A1	ZEB2
Description		collagen type XVI alpha 1 chain	zinc finger E-box binding homeobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Collagen Type XVI Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Phosphatase Regulator Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Cell Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Extracellular Matrix Organization Integrin Activation Cell Adhesion Mediated By Integrin Positive Regulation Of Focal Adhesion Assembly Cellular Response To Amino Acid Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Anatomical Structure Development Regulation Of Catalytic Activity Positive Regulation Of Canonical Wnt Signaling Pathway Melanocyte Migration Regulation Of Melanosome Organization
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059) Body mass index ( 26426971 25673413) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Severe aortic features in Marfan syndrome ( 30087447)	Adult body size ( 32376654) Adventurousness ( 30643258) Age-related nuclear cataracts ( 33311586) Childhood absence epilepsy ( 30531953) Chin dimples ( 27182965) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 30306274) Coronary artery disease ( 32469254 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 22949513) Hand grip strength ( 29691431) High myopia ( 31816047) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965 30899065) Red blood cell count ( 29403010) Refractive error ( 32231278) Renal cell carcinoma ( 23184150 25826619) Retinal detachment or retinal break ( 31816047) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 29483656 23974872) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)
Interacting Genes		1 interacting genes: ZEB2	13 interacting genes: APP CBX4 COL16A1 COPS6 CTBP1 CTBP2 GTDC1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I
Entrez ID		1307	9839
HPRD ID		00381	05780
Ensembl ID		ENSG00000084636	ENSG00000169554
Uniprot IDs		Q07092	O60315
PDB IDs			2DA7
Enriched GO Terms of Interacting Partners?
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