BBS5 and PRDM2

		BBS5	PRDM2
Description		Bardet-Biedl syndrome 5	PR/SET domain 2
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GO Annotations	Cellular Component	Cytosol Axoneme Centriolar Satellite BBSome Ciliary Basal Body Ciliary Membrane	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Zinc Ion Binding Histone Methyltransferase Activity Sequence-specific DNA Binding
	Biological Process	Heart Looping Visual Perception Protein Transport Melanosome Transport Motile Cilium Assembly Intracellular Transport Response To Stimulus Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Determination Of Adult Lifespan Regulation Of Gene Expression Histone Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Iris heterochromicity ( 30895295)	Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronotype ( 30696823) Copper levels ( 26025379) HDL cholesterol levels in HIV infection ( 33109212) Intracranial aneurysm ( 30823506) Left ventricular function change in anthracycline treatment ( 28542097) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Parkinson's disease ( 26227905) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Refractive error ( 32231278) Schizophrenia x sex interaction ( 34099189)
Interacting Genes		13 interacting genes: CFAP210 COTL1 CRADD CTSK EIF4EBP3 HRH1 KLC3 KLHL23 KLHL41 ORM2 PRDM2 SLC6A15 UBR3	9 interacting genes: BBS5 E2F1 ESR1 H3-4 H3C1 MDM2 PDPN RB1 TBCE
Entrez ID		129880	7799
HPRD ID		10353	03120
Ensembl ID		ENSG00000163093	ENSG00000116731
Uniprot IDs		A0A0S2Z626 Q8N3I7	Q13029
PDB IDs		6XTB	2JV0 2QPW
Enriched GO Terms of Interacting Partners?
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