COL8A1 and GLRX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		COL8A1	GLRX3
Description		collagen type VIII alpha 1 chain	glutaredoxin 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VIII Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Nucleus Cytosol Cell Cortex Z Disc Dendrite
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	RNA Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding Glutathione Oxidoreductase Activity
	Biological Process	Angiogenesis Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Endodermal Cell Differentiation Camera-type Eye Morphogenesis Epithelial Cell Proliferation	Regulation Of The Force Of Heart Contraction Cellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy [2Fe-2S] Cluster Assembly Protein Maturation By Iron-sulfur Cluster Transfer
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization	Iron uptake and transport
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636) Axial length ( 24144296) Body shape index ( 34021172) Childhood ear infection ( 27182965) Cleft lip with or without cleft palate ( 28054174) Hip index ( 34021172) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 31798171 25241763 28073927) Waist circumference adjusted for body mass index ( 34021172)	Alcohol dependence ( 26365420) Colorectal cancer ( 34062886) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Mean corpuscular volume ( 32888494) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Sleep end time ( 33075057) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		78 interacting genes: ADAMTSL4 ARMC5 BPIFA1 C11orf1 C19orf54 C22orf39 C9orf24 CCN3 CEP55 CIDEB COL8A2 CREB5 CYSRT1 DPEP2NB EFEMP2 FAM86C1P FBLN2 FBXO34 FRS3 GLRX3 GSC2 HOXA1 INCA1 ITGA1 ITGA2 KLHL12 KLHL20 KPRP KRT37 KRT40 KRT82 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LIMS1 MAJIN NADSYN1 NBPF19 NOTCH2NLA OTX1 PLSCR3 POF1B POU4F2 PPARA RBPMS REL RGS20 RHBDD2 SLC35A2 SP4 SPATA8 SPRY4 SSC4D TRIM35 UBQLN2 UBQLN4 VAC14 WFDC5 YPEL3 ZNF774 ZNHIT1	101 interacting genes: ADAMTSL3 ADAMTSL4 ALKBH3 BCL6 BOLA1 BOLA2 BOLA2B BOLA3 CA9 CBLB CCHCR1 CERCAM CGGBP1 CIAPIN1 COL8A1 DANCR EFEMP2 ERBB2 FAM118A FRA10AC1 GATA1 GMCL1 GNG13 GRN HEXD HSD3B7 IHO1 IKZF1 IL10 IRX6 KLHDC9 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2D LNX1 LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI METAP1 MOXD1 NADK NOTCH2NLA NTF4 OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ PRKD2 RCOR3 RECK REL RGS20 SMARCC1 SOX7 STAU1 STRA6 TCF4 TCL1B TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF124 ZNF148 ZNF23 ZNF426 ZNF490 ZNF512B ZNF544 ZNF774
Entrez ID		1295	10539
HPRD ID		00372	10153
Ensembl ID		ENSG00000144810	ENSG00000108010
Uniprot IDs		P27658	A0A140VJK1 O76003
PDB IDs			2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?
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