COL6A3 and GFRA3

		COL6A3	GFRA3
Description		collagen type VI alpha 3 chain	GDNF family receptor alpha 3
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GO Annotations	Cellular Component	Extracellular Region Collagen Type VI Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Sarcolemma Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle	Cytosol Plasma Membrane External Side Of Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength	Signaling Receptor Binding Protein Binding Axon Guidance Receptor Activity Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity
	Biological Process	Cell Adhesion Muscle Organ Development Negative Regulation Of Endopeptidase Activity	Neuron Migration Signal Transduction Nervous System Development Axon Guidance Peripheral Nervous System Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Sympathetic Nervous System Development
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization	RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Abstraction and mental flexibility ( 31596458) Aging (time to event) ( 21782286) Chronic kidney disease ( 30226566) Coronary artery disease ( 29212778 30402224 33020668) Cortex volume ( 31530798) HDL cholesterol ( 26160806) Heel bone mineral density ( 30598549) Height ( 33713608) Hypertension ( 30226566) Intraocular pressure ( 29617998 29235454) Ischemic stroke ( 29930801) LDL cholesterol ( 26160806) Lung cancer ( 28604730) Myocardial infarction ( 30226566) Pulse pressure ( 27841878)	Autism spectrum disorder or schizophrenia ( 28540026) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) QT interval ( 24952745) Schizophrenia ( 25056061)
Interacting Genes		12 interacting genes: ALPG CDT1 DYSF GBX2 GFRA3 KCNJ13 MMP2 NGFR PPT1 SEPTIN2 SUDS3 TRIT1	2 interacting genes: ARTN COL6A3
Entrez ID		1293	2676
HPRD ID		00371	10420
Ensembl ID		ENSG00000163359	ENSG00000146013
Uniprot IDs		B7ZW00 D9ZGF2 P12111 Q63HQ4 Q8N4Z1	O60609
PDB IDs		1KNT 1KTH 1KUN 2KNT 6SNK	2GH0 6Q2S
Enriched GO Terms of Interacting Partners?
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