COL6A1 and PDGFA

Number of citations of the paper that reports this interaction (PubMedID 8900172)
21

Data Source:
BioGRID (pull down)

		COL6A1	PDGFA
Description		collagen type VI alpha 1 chain	platelet derived growth factor subunit A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VI Trimer Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Membrane Protein-containing Complex Sarcolemma Collagen-containing Extracellular Matrix Extracellular Exosome	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Microvillus Cell Surface Platelet Alpha Granule Lumen
	Molecular Function	Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding Growth Factor Receptor Binding
	Biological Process	Osteoblast Differentiation Cell Adhesion Endodermal Cell Differentiation Cellular Response To Amino Acid Stimulus	Angiogenesis Cell Activation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Wounding Animal Organ Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Smooth Muscle Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Wound Healing Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Skin Development Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Glomerular Mesangial Cell Proliferation Embryonic Lung Development Regulation Of DNA Biosynthetic Process
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization	Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Corneal hysteresis ( 32716492 30894546) Corneal resistance factor ( 31246245 32716492 30894546) Daytime nap ( 33568662) Diverticular disease ( 30177863) Intraocular pressure ( 29617998 29235454) Keratoconus ( 33649486) Myopia ( 27182965) Pulse pressure ( 30224653 30578418) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 28234671) Waist circumference adjusted for body mass index ( 34021172 25673412)	Male-pattern baldness ( 28196072)
Interacting Genes		24 interacting genes: ALDH3A2 CFAP410 COL2A1 COL6A2 CSTB DCN DNAJB11 FAM3B FGF7 HCFC2 LAMB1 LCMT2 LGALS3BP MAG MLLT3 MPRIP MTDH PCNT PDGFA PDGFB PDK1 PEX26 PIGS RUNX1	17 interacting genes: A2M ASPH COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 DUSP3 FURIN HSPG2 MBD3 MDFI PDAP1 PDGFRA SPARC
Entrez ID		1291	5154
HPRD ID		00370	01424
Ensembl ID		ENSG00000142156	ENSG00000197461
Uniprot IDs		A0A384P5H7 P12109	P04085
PDB IDs			3MJK
Enriched GO Terms of Interacting Partners?
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