CDYL2 and DVL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CDYL2	DVL3
Description		chromodomain Y like 2	dishevelled segment polarity protein 3
Image
GO Annotations	Cellular Component	Nucleus	Chromatin Cytosol
	Molecular Function	Transcription Corepressor Activity Catalytic Activity Protein Binding Methylated Histone Binding	Protease Binding Signaling Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Transcription, DNA-templated	Positive Regulation Of Protein Phosphorylation Response To Xenobiotic Stimulus Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Neuron Projection Arborization Regulation Of Cellular Protein Localization
Pathways			TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Breast cancer ( 29059683 23535729) Inflammatory bowel disease ( 27569725) Interleukin-10 levels ( 22205395) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Prostate cancer ( 31748686) Pulse pressure ( 30224653) Serum alkaline phosphatase levels ( 33547301)	Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)
Interacting Genes		11 interacting genes: DVL3 H3-4 H3C1 HINFP HSF2BP LIG1 LMO3 NXF1 PRMT5 SPANXN2 ZBTB9	171 interacting genes: ABT1 ADAM15 ADAP1 AKAP17A ANKRD36B AP3M1 AXIN1 BAHD1 BCL6 BEND7 BHLHE40 C1orf35 C8orf33 CBX8 CCDC33 CCNK CCNL1 CDYL2 CEP57L1 CEP70 CEP76 CLK1 CSNK1D CSNK1E CSNK2A1 CT45A10 CT45A3 CTNNB1 CYSRT1 DAB2 DDX54 DIDO1 DPPA2 DVL1 EIF1B EIF3D ENKD1 EVI2A FAM13C FAM90A1 FARS2 FGF16 FLACC1 GADD45GIP1 HOMER3 HOXA5 HOXC5 HOXC8 INO80B KAT7 KAZN KCTD10 KCTD7 KLF1 KLF15 KLF3 KLF4 KLHL12 LENG8 LNX1 LONRF1 LRRK2 LUZP4 LY6H MAB21L3 MAGEB4 MAGOHB MARK2 MATN2 MBD1 NFYA NKD1 NOL12 NXF1 PATZ1 PDE6C PHF19 PIK3CB PITX1 PLAGL2 PLN PNKP PPM1A PPP1R16B PPP2CA PRKAA2 PRPF18 PRPF3 PRPF31 PRPF38A PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSME3 PSMF1 RAB18 RBM15B RBM39 RNF151 RPL11 RPS10 RPS5 RRP8 RWDD2B SAP30L SHFL SNIP1 SNX22 SORBS3 STOM SUV39H1 SYT6 SYTL4 TBPL1 TCEA2 TCEANC TFG THAP7 TLE5 TNFAIP8L1 TNP1 TPTEP2-CSNK1E TRAF2 TRIM41 TRIM54 TSN TSPYL1 TSPYL6 UTP3 VANGL1 VAX1 WDR25 WT1 XPA YTHDC1 ZBTB24 ZBTB26 ZBTB47 ZBTB48 ZBTB8A ZFP57 ZNF165 ZNF2 ZNF264 ZNF319 ZNF408 ZNF417 ZNF441 ZNF444 ZNF497 ZNF512B ZNF552 ZNF581 ZNF648 ZNF696 ZNF697 ZNF699 ZNF71 ZNF764 ZNF774 ZNF775 ZNF792 ZNF821 ZNF837 ZRSR2 ZSCAN21 ZSCAN22 ZSCAN25
Entrez ID		124359	1857
HPRD ID		10819	03222
Ensembl ID		ENSG00000166446	ENSG00000161202
Uniprot IDs		Q8N8U2	Q92997 Q9UG07
PDB IDs		2MJ8 4HAE 5JJZ 6V2D 6V2H 6V3N 6V8W	6V7O
Enriched GO Terms of Interacting Partners?
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