ERCC8 and ADAMTS6

		ERCC8	ADAMTS6
Description		ERCC excision repair 8, CSA ubiquitin ligase complex subunit	ADAM metallopeptidase with thrombospondin type 1 motif 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex	Extracellular Region Extracellular Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding	Metalloendopeptidase Activity Metallopeptidase Activity Metal Ion Binding
	Biological Process	Single Strand Break Repair Protein Polyubiquitination Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Response To UV Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Regulation Of Transcription-coupled Nucleotide-excision Repair Double-strand Break Repair Via Classical Nonhomologous End Joining	Kidney Development Cardiac Septum Development Proteolysis Extracellular Matrix Organization Aorta Development Coronary Vasculature Development
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442) Corneal structure ( 23291589) Corpus callosum anterior volume ( 31530798) Cortical surface area (MOSTest) ( 32665545) Feeling tense ( 29500382) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Inguinal hernia ( 26686553) Intraocular pressure ( 29617998 29785010 30054594) LDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Non-response to bupropion and depression ( 27622933) Osteosarcoma ( 23727862) Schizophrenia ( 23212062) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		12 interacting genes: ADAMTS6 CAMK2D CBR1 CSNK2B CUL4B DDB1 ERCC6 GTF2H2 RBX1 TOP1 UQCRQ XAB2	6 interacting genes: ARSB CD180 CDK7 ERCC8 PART1 SNTA1
Entrez ID		1161	11174
HPRD ID		07523	05421
Ensembl ID		ENSG00000049167	ENSG00000049192
Uniprot IDs		A0A0S2Z3L1 B3KPW7 B4DGZ9 Q13216	Q5IR90 Q9UKP5
PDB IDs		4A11 6FCV
Enriched GO Terms of Interacting Partners?
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