ARHGEF25 and PRKCG

Number of citations of the paper that reports this interaction (PubMedID 20395553)
15

Data Source:
BioGRID (pull down)

		ARHGEF25	PRKCG
Description		Rho guanine nucleotide exchange factor 25	protein kinase C gamma
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Myofibril Sarcomere	Nucleus Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Dendrite Calyx Of Held Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Rho Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Protein Phosphorylation Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Response To Toxic Substance Phosphorylation Peptidyl-serine Phosphorylation Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Response To Pain Rhythmic Process Regulation Of Phagocytosis Long-term Synaptic Potentiation Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Proteasomal Protein Catabolic Process Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis
Pathways		G alpha (q) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+
Drugs			Tamoxifen Fostamatinib
Diseases
GWAS		Systolic blood pressure ( 30224653 30578418)
Interacting Genes		5 interacting genes: CDC42 PRKCG RAC1 RHOA RHOU	66 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DDX58 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 LAIR1 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PABPC4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG
Entrez ID		115557	5582
HPRD ID		13573	01502
Ensembl ID		ENSG00000240771	ENSG00000126583
Uniprot IDs		Q86VW2	B2R5T1 B7Z3W6 P05129
PDB IDs		2RGN	2E73 2UZP
Enriched GO Terms of Interacting Partners?
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