CEP250 and MYL9

		CEP250	MYL9
Description		centrosomal protein 250	myosin light chain 9
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Centrosome Centriole Microtubule Organizing Center Cytosol Protein-containing Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Stress Fiber Cytosol Muscle Myosin Complex Cell Cortex Z Disc
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding	Calcium Ion Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding
	Biological Process	Mitotic Cell Cycle Protein Localization Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle Detection Of Light Stimulus Involved In Visual Perception Cilium Assembly Positive Regulation Of Protein Localization To Centrosome Non-motile Cilium Assembly	Regulation Of Muscle Contraction Platelet Aggregation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Brain morphology (MOSTest) ( 32665545) Height ( 25429064 18391951) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Ulcerative colitis ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: APP ATF7IP FAM83D FRMD5 ITCH KAT2B KCNG3 MYL9 NEK2 PDIA6 PHF20 PLEKHA5 TTI1 YWHAG	9 interacting genes: CDC42BPA CEP250 HSPB1 LRRK2 MSGN1 MYH9 PPP1R16B SLC12A5 TXN2
Entrez ID		11190	10398
HPRD ID		09877	17619
Ensembl ID		ENSG00000126001	ENSG00000101335
Uniprot IDs		Q9BV73	A0A384NY64 P24844
PDB IDs		6OQA
Enriched GO Terms of Interacting Partners?
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