WDR6 and SCAP

		WDR6	SCAP
Description		WD repeat domain 6	SREBF chaperone
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	RNA Binding Protein Binding Insulin Receptor Substrate Binding	Protein Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding
	Biological Process	Cell Cycle Negative Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy TRNA Methylation Regulation Of Cell Cycle	Response To Hypoxia Immune Response Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading
Pathways		RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Menarche (age at onset) ( 25231870) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: BRCA1 CDC42EP4 G2E3 GRIP1 PTPN3 SCAP	12 interacting genes: ATG16L1 DHX30 HIPK2 INSIG1 INSIG2 KLHL18 LAMC2 NDUFAF3 PGRMC1 SEC24B SREBF2 WDR6
Entrez ID		11180	22937
HPRD ID		06912	03300
Ensembl ID		ENSG00000178252	ENSG00000114650
Uniprot IDs		A0A087X295 B3KRR8 B4E256 E9PDU5 Q9H9M3 Q9NNW5	B7Z6H0 Q12770
PDB IDs			6M49
Enriched GO Terms of Interacting Partners?
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