TBC1D8 and SPP1

Number of citations of the paper that reports this interaction (PubMedID 22779921)
11

Data Source:
BioGRID (two hybrid)

		TBC1D8	SPP1
Description		TBC1 domain family member 8	secreted phosphoprotein 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding	Cytokine Activity Integrin Binding Protein Binding Extracellular Matrix Binding
	Biological Process	Intracellular Protein Transport Blood Circulation Positive Regulation Of Cell Population Proliferation Activation Of GTPase Activity Regulation Of Cilium Assembly	Osteoblast Differentiation Androgen Catabolic Process Inflammatory Response Cell Adhesion Signal Transduction Embryo Implantation Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Positive Regulation Of Estradiol Secretion
Pathways			Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Carotid intima media thickness x smoking interaction ( 32117412) Cognitive decline rate in late mild cognitive impairment ( 26252872) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29785010) Lymphocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Osteoporosis-related phenotypes ( 20548944) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)	Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)
Interacting Genes		3 interacting genes: SPP1 TRAF1 TRAF4	100 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CCR8 CD44 CD83 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PCDH7 PDLIM7 PEMT PEPD PLCB2 PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		11138	6696
HPRD ID		06752	01325
Ensembl ID		ENSG00000204634	ENSG00000118785
Uniprot IDs		J3KQ40 O95759	A0A024RDE2 A0A024RDE6 A0A024RDJ0 B7Z351 P10451 Q3LGB0
PDB IDs			3CXD 3DSF
Enriched GO Terms of Interacting Partners?
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