CHD4 and MBD3L2

Number of citations of the paper that reports this interaction (PubMedID 15701600)
15

Data Source:
BioGRID (pull down)

		CHD4	MBD3L2
Description		chromodomain helicase DNA binding protein 4	methyl-CpG binding domain protein 3 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Coregulator Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Nucleosomal DNA Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding ATP-dependent Chromatin Remodeler Activity	Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Duplex Unwinding
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Myopia (pathological) ( 23049088)
Interacting Genes		25 interacting genes: ATM ATR CD27 CSNK2A1 EP300 H2AC4 H2BC3 H3-4 H3C1 H4C1 HDAC1 IKZF4 MBD3L2 MTNR1A PSTPIP1 PTEN RNF8 RORC SMARCA4 SUMO2 TRIM27 TTN TWIST1 UBE2I XRN1	20 interacting genes: CCDC136 CHD4 GOLGA6L9 GPRASP2 HDAC1 HDAC2 KRT27 KRT34 KRTAP6-3 MBD2 MBD3 MDFI MTA1 MTA2 POLD3 RBBP4 RBBP7 RUNDC3A SBK3 TRIML2
Entrez ID		1108	125997
HPRD ID		04472	12139
Ensembl ID		ENSG00000111642	ENSG00000230522
Uniprot IDs		F5GWX5 Q14839	Q8NHZ7
PDB IDs		1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG 6Q3M 6RYR 6RYU
Enriched GO Terms of Interacting Partners?
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