TRIM31 and BTNL2

		TRIM31	BTNL2
Description		tripartite motif containing 31	butyrophilin like 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Signaling Receptor Binding
	Biological Process	Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Viral Release From Host Cell	Regulation Of Cytokine Production T Cell Receptor Signaling Pathway
Pathways		Interferon gamma signaling	Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Anger ( 24489884) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 28240269) Chronic obstructive pulmonary disease ( 33909500) Estimated glomerular filtration rate in diabetes ( 31451708) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Isovolumetric relaxation time ( 28394258) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252) Neuroticism ( 29255261) Prostate cancer ( 25217961) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic lupus erythematosus ( 32771030) Takayasu arteritis ( 33308445) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)	Adult asthma ( 27611488) Anti-cyclic Citrullinated Peptide Antibody ( 19287509) Apolipoprotein A1 levels ( 32203549) Asthma ( 23028483 21804548 27611488 31619474 29273806) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body shape index ( 34021172) Childhood steroid-sensitive nephrotic syndrome ( 29903748) Coronary heart disease ( 22751097) Crohn's disease ( 23850713) EGFR mutation-positive lung adenocarcinoma ( 27501781) Fibrinogen levels ( 28107422) Food antigen IgG levels ( 24962563) Frontotemporal dementia ( 24943344) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Height ( 28552196) Hemoglobin ( 29403010) Hepatitis B vaccine response ( 24282030) Hepatitis C induced liver cirrhosis ( 23321320) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) HIV-1 viral setpoint ( 26039976) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Knee osteoarthritis ( 20305777) Loneliness (multivariate analysis) ( 27629369) Lung adenocarcinoma ( 22797724) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte counts ( 32888494) Marginal zone lymphoma ( 25569183) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Multiple sclerosis (OCB status) ( 23472185) Primary biliary cholangitis ( 19458352) Prostate cancer ( 23535732) Response to hepatitis B vaccine ( 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis ( 22936702) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Serum alkaline phosphatase levels ( 29403010) SjÃ¶gren's syndrome ( 24097066) Takayasu arteritis ( 25604533) Tuberculosis ( 29036319) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 19915573 28067908 20228799 18836448 21297633 19122664) Venous thromboembolism ( 33592630) Vitiligo ( 20410501 21326295) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		22 interacting genes: BTNL2 CCT6A EID3 IKBKG MAGEA1 MAGEA2B MKRN3 MNAT1 NSMCE4A TRAF2 TRIM23 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2W USP7 ZSCAN1	2 interacting genes: TRIM31 TRIM39
Entrez ID		11074	56244
HPRD ID		10281	12077
Ensembl ID		ENSG00000204616	ENSG00000204290
Uniprot IDs		Q2L6J1 Q9BZY9	A0PJV4 F8WBA1 Q9UIR0
PDB IDs		2YSJ 2YSL
Enriched GO Terms of Interacting Partners?
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