DDX52 and HLCS

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		DDX52	HLCS
Description		DExD-box helicase 52	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Membrane	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	RNA Binding RNA Helicase Activity ATP Binding ATP Hydrolysis Activity	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding
	Biological Process	Maturation Of SSU-rRNA	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs			Biotin
Diseases
GWAS		Ovarian cancer ( 23535730)	Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		5 interacting genes: AP4M1 HLCS MTNR1A PMP22 UTP23	17 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 SNX27 SOD1 SPATA46 TGM3 WIPF1
Entrez ID		11056	3141
HPRD ID		09911	08360
Ensembl ID		ENSG00000278053	ENSG00000159267
Uniprot IDs		B3KM65 Q9Y2R4	P50747
PDB IDs		3DKP
Enriched GO Terms of Interacting Partners?
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